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ASC、Ipaf和冷吡啉/Nalp3：半胱天冬酶-1炎性小体真正的细胞内衔接蛋白。

ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome.

作者信息

Mariathasan Sanjeev

机构信息

Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

出版信息

Microbes Infect. 2007 Apr;9(5):664-71. doi: 10.1016/j.micinf.2007.01.017. Epub 2007 Jan 27.

DOI:10.1016/j.micinf.2007.01.017
PMID:17382568
Abstract

The adapter molecules ASC, Ipaf and Cryopyrin/Nalp3 have each been proposed to regulate caspase-1 within a multi-protein complex called the "inflammasome". Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin (IL)-1beta and IL-18. The analysis of mice deficient in ASC, Ipaf and Cryopyrin/Nalp3 has revealed that the inflammasome is a dynamic entity that is assembled from different adapters in a stimulus-dependent manner.

摘要

衔接分子ASC、Ipaf和Cryopyrin/Nalp3均被认为可在一种名为“炎性小体”的多蛋白复合物中调节半胱天冬酶-1。半胱天冬酶-1的激活会导致促炎细胞因子如白细胞介素（IL）-1β和IL-18的切割与激活。对ASC、Ipaf和Cryopyrin/Nalp3基因敲除小鼠的分析表明，炎性小体是一个动态实体，它以刺激依赖的方式由不同的衔接分子组装而成。

相似文献

[1]
ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome.

Microbes Infect. 2007-4

[2]
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Immunol Rev. 2009-1

[3]
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.

Cell Death Differ. 2007-9

[4]
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.

Nature. 2006-3-9

[5]
Cryopyrin activates the inflammasome in response to toxins and ATP.

Nature. 2006-3-9

[6]
NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding.

J Biol Chem. 2017-7-28

[7]
Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.

Immunity. 2007-4

[8]
The inflammasome in pathogen recognition and inflammation.

J Leukoc Biol. 2007-8

[9]
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

Nat Immunol. 2009-3

[10]
Inflammasomes in liver diseases.

J Hepatol. 2012-5-23

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