ASC、Ipaf和冷吡啉/Nalp3：半胱天冬酶-1炎性小体真正的细胞内衔接蛋白。
ASC, Ipaf and Cryopyrin/Nalp3: bona fide intracellular adapters of the caspase-1 inflammasome.
作者信息
Mariathasan Sanjeev
机构信息
Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
出版信息
Microbes Infect. 2007 Apr;9(5):664-71. doi: 10.1016/j.micinf.2007.01.017. Epub 2007 Jan 27.
The adapter molecules ASC, Ipaf and Cryopyrin/Nalp3 have each been proposed to regulate caspase-1 within a multi-protein complex called the "inflammasome". Activation of caspase-1 leads to the cleavage and activation of pro-inflammatory cytokines such as interleukin (IL)-1beta and IL-18. The analysis of mice deficient in ASC, Ipaf and Cryopyrin/Nalp3 has revealed that the inflammasome is a dynamic entity that is assembled from different adapters in a stimulus-dependent manner.
衔接分子ASC、Ipaf和Cryopyrin/Nalp3均被认为可在一种名为“炎性小体”的多蛋白复合物中调节半胱天冬酶-1。半胱天冬酶-1的激活会导致促炎细胞因子如白细胞介素（IL）-1β和IL-18的切割与激活。对ASC、Ipaf和Cryopyrin/Nalp3基因敲除小鼠的分析表明，炎性小体是一个动态实体，它以刺激依赖的方式由不同的衔接分子组装而成。
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