Sutterwala Fayyaz S, Ogura Yasunori, Flavell Richard A
Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
J Leukoc Biol. 2007 Aug;82(2):259-64. doi: 10.1189/jlb.1206755. Epub 2007 Apr 30.
The nucleotide-binding oligomerization domain-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Some NLR family members promote the activation of proinflammatory caspases within multiprotein complexes, called inflammasomes. Recent studies analyzing mice deficient in various components of the inflammasome have provided insight into the role of these molecules in host defense against pathogens and in autoinflammatory disorders. Here, we review these studies and propose that membrane disruption leads to activation of the inflammasome.
核苷酸结合寡聚化结构域样受体（NLR）蛋白家族参与先天免疫反应和细胞死亡途径的调节。一些NLR家族成员可促进多蛋白复合物（称为炎性小体）内促炎半胱天冬酶的激活。最近对炎性小体各种成分缺陷小鼠的研究，为这些分子在宿主抵御病原体和自身炎症性疾病中的作用提供了深入了解。在此，我们综述这些研究，并提出膜破坏会导致炎性小体的激活。
