十字叶钟铃木（紫葳科）茎中的环烯醚萜苷。

Iridoid glycosides from the stems of Pithecoctenium crucigerum (Bignoniaceae).

作者信息

Martin Frédéric, Hay Anne-Emmanuelle, Corno Laura, Gupta Mahabir P, Hostettmann Kurt

机构信息

Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.

出版信息

Phytochemistry. 2007 May;68(9):1307-11. doi: 10.1016/j.phytochem.2007.02.002. Epub 2007 Mar 23.

DOI:10.1016/j.phytochem.2007.02.002

PMID:17382978

Abstract

Sixteen crude extracts from six Panamanian plants of the family Bignoniaceae were submitted to rapid TLC tests against DPPH and acetylcholinesterase. Pithecoctenium crucigerum (L.) A.H. Gentry, which showed interesting activity against DPPH, has been studied. The chemical investigation of the methanol extract from the stems afforded the iridoid glycoside theviridoside and three derivatives (6'-O-cyclopropanoyltheviridoside, 10-O-hydroxybenzoyltheviridoside and 10-O-vanilloyltheviridoside), along with five known phenylethanoid glycosides (verbascoside, isoverbascoside, forsythoside B, jionoside D and leucosceptoside B). These last compounds were all active against DPPH. The structures were determined by means of spectrometric and chemical methods, including 1D and 2D NMR experiments and MS analysis.

摘要

对来自巴拿马紫葳科六种植物的十六种粗提物进行了针对二苯基苦味酰基自由基（DPPH）和乙酰胆碱酯酶的快速薄层色谱（TLC）测试。已对显示出有趣的抗DPPH活性的十字叶钟树（Pithecoctenium crucigerum (L.) A.H. Gentry）进行了研究。对该植物茎部甲醇提取物的化学研究得到了环烯醚萜苷绿玉苷及其三种衍生物（6'-O-环丙酰基绿玉苷、10-O-羟基苯甲酰基绿玉苷和10-O-香草酰基绿玉苷），以及五种已知的苯乙醇苷（毛蕊花糖苷、异毛蕊花糖苷、连翘酯苷B、紫茎女贞苷D和白刺花苷B）。这些最后提到的化合物均具有抗DPPH活性。通过光谱和化学方法确定了其结构，包括一维和二维核磁共振实验以及质谱分析。