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陶西格-宾畸形动脉调转术的手术结果:大动脉位置是危险因素吗?

Surgical results of arterial switch operation for Taussig-Bing anomaly: is position of the great arteries a risk factor?

作者信息

Rodefeld Mark D, Ruzmetov Mark, Vijay Palaniswamy, Fiore Andrew C, Turrentine Mark W, Brown John W

机构信息

Section of Cardiothoracic Surgery, James W. Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, Indiana 46202-5123, USA.

出版信息

Ann Thorac Surg. 2007 Apr;83(4):1451-7. doi: 10.1016/j.athoracsur.2006.10.072.

Abstract

BACKGROUND

A variety of definitive operations have been used to manage patients with double-outlet right ventricle and subpulmonary ventricular septal defect (Taussig-Bing anomaly). This study identifies the impact of the position of the great arteries and use of a staged surgical approach on the outcome after the arterial switch operation in children with Taussig-Bing anomaly.

METHODS

From 1986 through July 2005, 34 patients with Taussig-Bing anomaly underwent the arterial switch operation. The median age at operation was 21 days. Based on position of the great arteries, patients were divided into group I (side by side; n = 16) and group II (anteroposterior; n = 18). Aortic arch obstruction was present in 18 patients (53%), of whom 16 had prior repair with aortic arch reconstruction. Abnormal coronary artery patterns were present in 9 patients (27%).

RESULTS

There were 4 early deaths and 1 late death (3 from group I and 2 from group II). The actuarial survival rate was 85% at 15 years (81% in group I and 89% in group II). Right ventricular outflow tract obstruction (mean gradient, 46.0 +/- 5.5 mm Hg) developed in 5 cases (2 from group I and 3 from group II). One patient underwent reoperation for residual aortic arch obstruction. Freedom from reoperation was 80% at 15 years, and thereafter 85% in group I and 75% in group II. Statistical analysis of potential risk factors revealed no significant identifiers for death or need for reoperation between groups.

CONCLUSIONS

The arterial switch operation remains our preferred choice of treatment for children with Taussig-Bing anomaly. The position of the great arteries has no effect on postoperative morbidity and mortality. In the presence of aortic arch obstruction, staged arch reconstruction followed soon thereafter by early intracardiac repair has yielded excellent outcomes in our experience.

摘要

背景

多种确定性手术已被用于治疗右心室双出口合并肺动脉下室间隔缺损(陶西格-宾氏畸形)的患者。本研究确定大动脉位置和分期手术方法对陶西格-宾氏畸形患儿动脉调转手术后结局的影响。

方法

1986年至2005年7月,34例陶西格-宾氏畸形患者接受了动脉调转手术。手术时的中位年龄为21天。根据大动脉位置,患者分为I组(并列;n = 16)和II组(前后位;n = 18)。18例患者(53%)存在主动脉弓梗阻,其中16例曾接受主动脉弓重建修复术。9例患者(27%)存在异常冠状动脉模式。

结果

有4例早期死亡和1例晚期死亡(I组3例,II组2例)。15年时的精算生存率为85%(I组为81%,II组为89%)。5例患者(I组2例,II组3例)出现右心室流出道梗阻(平均压差,46.0±5.5 mmHg)。1例患者因残留主动脉弓梗阻接受了再次手术。15年时再次手术的自由度为80%,此后I组为85%,II组为75%。对潜在危险因素的统计分析显示,两组之间在死亡或再次手术需求方面没有显著的识别因素。

结论

动脉调转手术仍然是我们治疗陶西格-宾氏畸形患儿的首选治疗方法。大动脉的位置对术后发病率和死亡率没有影响。在存在主动脉弓梗阻的情况下,根据我们的经验,分期进行弓部重建并随后尽早进行心内修复已取得了优异的结果。

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