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本文引用的文献

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Predicting Shine-Dalgarno sequence locations exposes genome annotation errors.预测夏因-达尔加诺序列位置可揭示基因组注释错误。
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Pentapeptide repeat proteins.五肽重复蛋白
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The integration of macromolecular diffraction data.大分子衍射数据的整合
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An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium.点状念珠藻的基因组概述，一种多细胞共生蓝细菌。
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Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase.质粒编码的喹诺酮耐药蛋白Qnr与大肠杆菌DNA促旋酶的相互作用。
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wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models.wARP：通过多个精修虚拟原子模型的加权平均改进和扩展晶体学相位
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Regulation of manganese uptake in Synechocystis 6803 by RfrA, a member of a novel family of proteins containing a repeated five-residues domain.RfrA对集胞藻6803中锰摄取的调控，RfrA是一个包含重复五残基结构域的新型蛋白质家族的成员。
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来自点状念珠藻的两种五肽重复蛋白Np275和Np276融合体的结构表征：一种祖先蛋白的复活

Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.

作者信息

Vetting Matthew W, Hegde Subray S, Hazleton Keith Z, Blanchard John S

机构信息

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

出版信息

Protein Sci. 2007 Apr;16(4):755-60. doi: 10.1110/ps.062637707.

DOI:10.1110/ps.062637707
PMID:17384236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2203339/
Abstract

The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein.

摘要

点状念珠藻基因Np275和Np276是两个相邻编码的蛋白质，长度分别为98和75个氨基酸，并呈现出由串联五肽重复序列组成的序列。Np275以及Np275与Np276的融合蛋白的结构分别被测定为2.1 Å和1.5 Å。这两种念珠藻蛋白折叠成高度对称的右手四边形β-螺旋，类似于与氟喹诺酮耐药性和DNA回旋酶抑制有关的分枝杆菌蛋白MfpA。中间编码区的序列组成以及通过去除Np275的终止密码子来表达融合蛋白的能力表明，Np275和Np276最近是一个更大的祖先五肽重复蛋白的一部分。