Hendrix Mary J C, Seftor Elisabeth A, Seftor Richard E B, Kasemeier-Kulesa Jennifer, Kulesa Paul M, Postovit Lynne-Marie
Cancer Biology and Epigenomics Program, Children's Memorial Research Centre, Robert H. Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA.
Nat Rev Cancer. 2007 Apr;7(4):246-55. doi: 10.1038/nrc2108.
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration.
侵袭性肿瘤细胞与胚胎祖细胞具有许多共同特征，这导致了肿瘤细胞可塑性的难题。最近使用人类干细胞、斑马鱼和鸡的胚胎模型进行的研究表明，侵袭性黑色素瘤细胞的转移表型发生了逆转，并揭示了胚胎信号通路与致瘤信号通路的趋同，这可能有助于确定新的治疗干预靶点。本综述将总结用于逆转转移性黑色素瘤表型的胚胎模型，并强调那些已成为未来值得考虑的重要靶点的显著信号通路。
