Bai Jinping, Yang Gege, Yu Qi, Chi Qianya, Zeng Xianlu, Qi Wenjing
Department of Bioscience, Changchun Normal University, Changchun, China.
Key Laboratory of Molecular Epigenetics of Ministry of Education, College of Life Sciences, Northeast Normal University, Changchun, China.
Front Oncol. 2025 Feb 25;15:1535929. doi: 10.3389/fonc.2025.1535929. eCollection 2025.
Cancer remains a major global health challenge, with prostate cancer, lung cancer, colorectal cancer, and breast cancer accounting for nearly half of all diagnoses. Despite advancements in cancer treatment, metastasis to distant organs continues to be the leading cause of cancer-related mortality. The progression of cancer involves the alteration of numerous genes, with dynamic changes in chromatin organization and histone modifications playing a critical role in regulating cancer-associated genes. Special AT-rich sequence-binding protein 1 (SATB1), a critical chromatin organizer, plays a pivotal role in cancer progression by regulating gene expression, chromatin remodeling, and cell signaling pathways. SATB1 binds to AT-rich DNA sequences, acting as a scaffold for chromatin-modifying enzymes and transcription factors, thus coordinating the regulation of extensive gene networks. Its overexpression has been implicated in a wide range of cancers and is associated with poor prognosis, aggressive tumor phenotypes, and enhanced epithelial-mesenchymal transition (EMT). Moreover, SATB1's activity is modulated by microRNAs (miRNAs) and post-translational modifications, further contributing to its complex regulatory functions. Given its crucial involvement in cancer progression and metastasis, SATB1 has emerged as a promising target for novel therapeutic strategies. This review delves into the molecular mechanisms of SATB1 in cancer and explores potential therapeutic approaches for targeting this key regulator in cancer treatment.
癌症仍然是一项重大的全球健康挑战，前列腺癌、肺癌、结直肠癌和乳腺癌占所有诊断病例的近一半。尽管癌症治疗取得了进展，但远处器官转移仍然是癌症相关死亡的主要原因。癌症的进展涉及众多基因的改变，染色质组织和组蛋白修饰的动态变化在调节癌症相关基因中起着关键作用。特殊富含AT序列结合蛋白1（SATB1）是一种关键的染色质组织者，通过调节基因表达、染色质重塑和细胞信号通路在癌症进展中起关键作用。SATB1与富含AT的DNA序列结合，作为染色质修饰酶和转录因子的支架，从而协调广泛基因网络的调节。其过表达与多种癌症有关，并与预后不良、侵袭性肿瘤表型和上皮-间质转化（EMT）增强有关。此外，SATB1的活性受微小RNA（miRNA）和翻译后修饰的调节，进一步促成其复杂的调节功能。鉴于其在癌症进展和转移中的关键作用，SATB1已成为新型治疗策略的一个有前景的靶点。本综述深入探讨了SATB1在癌症中的分子机制，并探索了在癌症治疗中靶向这一关键调节因子的潜在治疗方法。
