Williams R Scott, Tainer John A
Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, MB4, La Jolla, CA 92037, USA.
Mol Cell. 2007 Mar 23;25(6):789-91. doi: 10.1016/j.molcel.2007.03.004.
In groundbreaking work, Bhaskara et al. (2007) demonstrate in a recent issue of Molecular Cell that the Mre11/Rad50/Nbs1 (MRN) complex harbors distinct, yet chemically related, ATPase and adenylate kinase catalytic activities that together orchestrate multiple requisite MRN functional and conformational states in dsDNA break repair sensing and signaling with general implications for ABC ATPases.
在一项具有开创性的研究中，巴斯卡拉等人（2007年）在最近一期的《分子细胞》杂志上证明，Mre11/Rad50/Nbs1（MRN）复合物具有独特但化学性质相关的ATP酶和腺苷酸激酶催化活性，这些活性共同协调了双链DNA断裂修复感应和信号传导中多个必需的MRN功能和构象状态，这对ABC ATP酶具有普遍意义。
