Daniels Anthony B, Liu Grant T, Volpe Nicholas J, Galetta Steven L, Moster Mark L, Newman Nancy J, Biousse Valerie, Lee Andrew G, Wall Michael, Kardon Randy, Acierno Marie D, Corbett James J, Maguire Maureen G, Balcer Laura J
Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Am J Ophthalmol. 2007 Apr;143(4):635-41. doi: 10.1016/j.ajo.2006.12.040.
Obesity and weight gain are known risk factors for idiopathic intracranial hypertension (IIH; or pseudotumor cerebri). The authors examined profiles of body mass index (BMI) and patterns of weight gain associated with IIH. They also examined vision-specific health-related quality of life (HRQOL) in newly diagnosed IIH patients and explored the relative contribution of obesity and weight gain to overall HRQOL in this disorder.
Matched case-control study.
Female patients with newly diagnosed IIH (n = 34) and other neuro-ophthalmologic disorders (n = 41) were enrolled in a case-control study to assess patterns of self-reported weight gain. The HRQOL was examined using the 25-Item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the SF-36 Health Survey (Physical Components Summary and Mental Components Summary [MCS]).
Higher BMIs were associated with greater risk of IIH (P = .003, logistic regression analysis adjusting for case-control matching), as were higher percentages of weight gain during the year before symptom onset (P = .004). Moderate weight gain (5% to 15%) was associated with a greater risk of IIH among both obese and nonobese patients. Obesity and weight gain influenced the relation between HRQOL and IIH only for subscale scores reflecting mental health (SF-36 MCS). The NEI-VFQ-25 and SF-36 subscale scores were lower in IIH compared with other neuro-ophthalmologic disorders and published norms.
Higher levels of weight gain and BMI are associated with greater risk of IIH. Even nonobese patients (BMI <30) are at greater risk for IIH in the setting of moderate weight gain. Vision-specific and overall HRQOL are affected to a greater extent in IIH than in other neuro-ophthalmologic disorders.
肥胖和体重增加是特发性颅内高压（IIH；或假性脑瘤）已知的风险因素。作者研究了与IIH相关的体重指数（BMI）概况和体重增加模式。他们还研究了新诊断的IIH患者特定于视力的健康相关生活质量（HRQOL），并探讨了肥胖和体重增加对该疾病总体HRQOL的相对影响。
匹配病例对照研究。
新诊断为IIH的女性患者（n = 34）和其他神经眼科疾病患者（n = 41）被纳入一项病例对照研究，以评估自我报告的体重增加模式。使用25项国家眼科研究所视觉功能问卷（NEI-VFQ-25）和SF-36健康调查（身体成分总结和精神成分总结[MCS]）来检查HRQOL。
较高的BMI与IIH风险增加相关（P = 0.003，经病例对照匹配调整的逻辑回归分析），症状发作前一年体重增加的百分比更高也与之相关（P = 0.004）。中等程度的体重增加（5%至15%）在肥胖和非肥胖患者中均与IIH风险增加相关。肥胖和体重增加仅对反映心理健康的子量表评分（SF-36 MCS）影响HRQOL与IIH之间的关系。与其他神经眼科疾病和已发表的标准相比，IIH患者的NEI-VFQ-25和SF-36子量表评分更低。
体重增加和BMI水平较高与IIH风险增加相关。即使是非肥胖患者（BMI <30），在中等程度体重增加的情况下患IIH的风险也更高。与其他神经眼科疾病相比，IIH患者特定于视力的和总体的HRQOL受到的影响更大。
