Chan Yiu-Han, Wong Kim Ming, Kwok Philip Chong-Hei, Liu Allen Yan-Lun, Choi Koon Shing, Chau Ka Foon, Li Chun Sang
Department of Medicine, Renal Unit, Queen Elizabeth Hospital, Hong Kong, SAR.
Am J Kidney Dis. 2007 Apr;49(4):547-51. doi: 10.1053/j.ajkd.2007.01.010.
We report an unusual case of veno-caliceal fistula that developed because of high ureteric pressure caused by graft ureteric stricture after kidney transplantation in a 60-year-old patient. We further confirmed its presence with radiological images. Recirculation of creatinine and other uremic toxins resulted in a biochemical picture of renal failure in the presence of normal kidney function, confirmed by normal scintigraphy findings. Drainage of the pelvi-caliceal system could not be assessed accurately by means of diuretic renogram using technetium-99m diethylenetriaminepentaacetic acid with frusemide because of the rapid clearance of tracer activity from the system in the presence of a veno-caliceal fistula. The patient's renal function improved rapidly after interrupting urine recirculation by using percutaneous drainage, confirming "pseudo renal failure" as the cause of his persistently increased serum creatinine concentration. The ureter was re-implanted later, and the veno-caliceal fistula was not seen in the nephrostogram after the operation. He remains well with stable renal function at 3 years' follow-up. Clinicians should exercise judgment when evaluating patients with allograft dysfunction, especially when the investigation and clinical findings show contradicting results.
我们报告了一例罕见的肾盂静脉瘘病例,该病例发生在一名60岁患者肾移植后,因移植输尿管狭窄导致输尿管压力升高所致。我们通过影像学检查进一步证实了其存在。肌酐和其他尿毒症毒素的再循环导致在肾功能正常的情况下出现肾衰竭的生化表现,肾闪烁显像结果正常证实了这一点。由于存在肾盂静脉瘘,使用锝-99m二乙三胺五乙酸加呋塞米进行利尿肾图检查时,无法准确评估肾盂肾盏系统的引流情况。通过经皮引流中断尿液再循环后,患者的肾功能迅速改善,证实“假性肾衰竭”是其血清肌酐浓度持续升高的原因。后来重新植入了输尿管,术后肾造影片中未再见到肾盂静脉瘘。在3年的随访中,他肾功能稳定,状况良好。临床医生在评估移植肾功能不全的患者时应谨慎判断,尤其是当检查和临床结果相互矛盾时。