Moroson H, Schmid M, Furlan M
Division of Physical Biology, Sloan-Kettering Institute for Cancer Research, Rye, New York, USA.
Radiat Res. 1968 Dec;36(3):571-9.
Female mice bearing the Ehrlich carcinoma or P388 lymphocytic leukemia tumors in ascites form were given sublethal doses of whole-body x-irradiation and the thiol binding agents N-ethylmaleimide, hydroxy-mercuribenzoate, or iodoacetamide, injected intraperitoneally prior to irradiation, as a single treatment. These compounds were found previously to sensitize mice to radiation lethality. Enhanced tumor cell killing was observed as measured by tumor cell count, along with slightly longer survival times of the host animal. Increasing the dose of either radiation or drug alone also caused an increase in tumor cell killing, but at the expense of earlier mortality of the host animal. At the doses employed the sensitizers examined appeared more effective on these two ascites tumors han on the host. The mechanism of enhancement of radiation killing of tumor cells by these drugs is not clear, although it appears not to be due to additive toxicity effects. Similar experiments with several cancer chemotherapy agents showed that those compounds did not act as radiosensitizers.
对患有腹水型艾氏癌或P388淋巴细胞白血病肿瘤的雌性小鼠给予亚致死剂量的全身X射线照射，并在照射前腹腔注射硫醇结合剂N-乙基马来酰亚胺、羟基汞苯甲酸盐或碘乙酰胺，作为单一治疗。这些化合物先前被发现可使小鼠对辐射致死敏感。通过肿瘤细胞计数测量观察到肿瘤细胞杀伤增强，同时宿主动物的存活时间略有延长。单独增加辐射剂量或药物剂量也会导致肿瘤细胞杀伤增加，但以宿主动物更早死亡为代价。在所使用的剂量下，所检测的敏化剂对这两种腹水肿瘤似乎比对宿主更有效。尽管这些药物增强肿瘤细胞辐射杀伤的机制尚不清楚，但似乎不是由于相加毒性作用。对几种癌症化疗药物进行的类似实验表明，这些化合物不作为放射增敏剂起作用。
