Niederhäuser U, Vogt M, von Segesser L K, Carrel T, Bauersfeld U, Laske A, Bauer E, Schönbeck M, Turina M
Klinik für Herzgefässchirurgie, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1992 Feb 1;122(5):158-60.
Between 1980 and 1990 12 patients (5 male, 7 female) were operated on for acute infectious pericarditis at a mean age of 42 years. The infections were 6 bacterial (purulent 4, abscess 2), 4 tuberculous, 1 viral and 1 Candida. Pericarditis resulted from contiguous spread of infection from bilateral pneumonia in 3 patients, from subphrenic abscess in 2 and followed bacteremia in 1. Clinical signs were: tamponade/shock in 9, elevated jugular venous pressure in 11, edema in 6, hepatomegaly in 6, ascites in 1, and pericardial friction rub in 3. A preoperative pericardiocentesis in 9 patients allowed only 4 positive microbiological diagnoses and was an insufficient drainage in all cases. The preoperative mean NYHA class was 3.3. The pericardectomy was total in 9 patients and partial in 3. Total mortality was 1/12 patients (8%) with one late death due to recurrent tuberculous pericarditis. No patient with purulent pericarditis died. Another recurrence occurred 6 months after acute viral pericarditis. Atrial fibrillation in one patient was the only postoperative complication. After a mean follow-up period of 48.5 months no cardiac constriction had occurred in 11 surviving patients Actuarial survival after pericardectomy is 100% after 1 month and remains 91% after 5 years. The mean NYHA class has significantly improved to 1.2 (p less than 0.05) at the end of the follow-up. We conclude that pericardectomy combined with a specific antimicrobial therapy is a safe treatment for acute infectious and especially purulent pericarditis with low mortality and excellent longterm results. Early pericardectomy allows rapid decompression of the heart, removal of intrapericardial adhesions and infected tissue and prevents late constriction.(ABSTRACT TRUNCATED AT 250 WORDS)
1980年至1990年间,12例患者(5例男性,7例女性)接受了急性感染性心包炎手术,平均年龄42岁。感染类型为:细菌性6例(脓性4例,脓肿2例),结核性4例,病毒性1例,念珠菌性1例。3例患者的心包炎是由双侧肺炎感染蔓延所致,2例由膈下脓肿引起,1例继发于菌血症。临床症状包括:9例有心脏压塞/休克,11例颈静脉压升高,6例水肿,6例肝肿大,1例腹水,3例有心包摩擦音。9例患者术前行心包穿刺术,仅4例获得阳性微生物诊断,且所有病例引流均不充分。术前平均纽约心脏协会(NYHA)心功能分级为3.3级。9例行全心包切除术,3例行部分心包切除术。总死亡率为1/12例患者(8%),1例因复发性结核性心包炎晚期死亡。脓性心包炎患者无死亡病例。急性病毒性心包炎6个月后出现另一例复发。1例患者术后出现房颤,为唯一并发症。平均随访48.5个月后,11例存活患者未发生心脏缩窄。心包切除术后1个月的精算生存率为100%,5年后仍为91%。随访结束时,平均NYHA心功能分级显著改善至1.2级(p<0.05)。我们得出结论,心包切除术联合特异性抗菌治疗是治疗急性感染性尤其是脓性心包炎的安全方法,死亡率低,长期效果良好。早期心包切除术可使心脏迅速减压,清除心包内粘连和感染组织,防止晚期缩窄。(摘要截选至250字)