Melzer David, Hurst Alison J, Frayling Tim
Peninsula Medical School, University of Exeter, Exeter, UK.
J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):301-7. doi: 10.1093/gerona/62.3.301.
The genetics of aging has seen extraordinary progress over the last few decades, with animal models suggesting key roles for a number of metabolic pathways. However, humans outlive laboratory models many times over, and only evidence from humans can ultimately identify the drivers of human aging. In this article we thematically review progress in identifying human genetic variants associated with longevity. We also look at the bigger picture of progress in identifying genetic associates of disease and functioning and healthy aging in older people. Although much of the existing evidence is fragmentary, recent exciting findings and robust methods are taking the field rapidly forward.
在过去几十年里，衰老遗传学取得了非凡进展，动物模型表明许多代谢途径发挥着关键作用。然而，人类的寿命比实验室模型长得多，只有来自人类的证据才能最终确定人类衰老的驱动因素。在本文中，我们将专题回顾在识别与长寿相关的人类基因变异方面所取得的进展。我们还将审视在识别疾病的基因关联以及老年人的功能和健康衰老方面取得的整体进展。尽管现有证据大多支离破碎，但最近令人兴奋的发现和可靠的方法正在推动该领域迅速向前发展。
