Flaster Harry, Bernhagen Jürgen, Calandra Thierry, Bucala Richard
Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Mol Endocrinol. 2007 Jun;21(6):1267-80. doi: 10.1210/me.2007-0065. Epub 2007 Mar 27.
The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.
细胞因子巨噬细胞移动抑制因子（MIF）因其直接调节糖皮质激素免疫抑制作用的能力，在生理学中占据独特地位。我们在此综述免疫系统中MIF与糖皮质激素之间的相互作用，并讨论MIF - 糖皮质激素调节二元组在生理学和免疫病理学中的相关性。对MIF的治疗性拮抗可能是难治性自身免疫或炎症性疾病患者进行激素节省疗法的有效方法。
