Stosic-Grujicic Stanislava, Stojanovic Ivana, Nicoletti Ferdinando
Institute for Biological Research Sinisa Stankovic, Belgrade, Serbia.
Autoimmun Rev. 2009 Jan;8(3):244-9. doi: 10.1016/j.autrev.2008.07.037. Epub 2008 Aug 20.
Macrophage migration inhibitory factor (MIF) is a multipotent cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune disorders. Since anti-cytokine therapy is considered to be a promising therapeutic strategy, selective targeting of MIF with either anti-MIF antibody or specific chemical MIF inhibitors might offer new therapeutic avenues for these disorders. Considering the unique relationship between MIF and glucocorticoids, therapeutic antagonism of MIF could also represent an effective approach for steroid-sparing therapies in patients with refractory autoimmune diseases.
巨噬细胞移动抑制因子（MIF）是一种多效性细胞因子，与多种炎症和自身免疫性疾病的发病机制有关。由于抗细胞因子疗法被认为是一种有前景的治疗策略，用抗MIF抗体或特定的化学MIF抑制剂选择性靶向MIF可能为这些疾病提供新的治疗途径。考虑到MIF与糖皮质激素之间的独特关系，对MIF进行治疗性拮抗也可能是难治性自身免疫性疾病患者进行类固醇节省疗法的有效方法。
