Hwang S J, Lai Y H, Chen H C, Tsai J H
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Am J Kidney Dis. 1992 Jan;19(1):57-60. doi: 10.1016/s0272-6386(12)70203-2.
Because aluminum hydroxide, as a phosphate binder, lowered intestinal zinc absorption, we studied the effects of calcium carbonate (CaCO3) and calcium acetate (CaAc), two other phosphate binders, on intestinal Zn absorption in nine patients on hemodialysis and in 11 controls by measuring 1- and 2-hour serum Zn levels after oral administration of 50 mg of elemental Zn as Zn gluconate with or without concomitant administration of 2 g CaCO3 (800 mg elemental Ca) or 3 g CaAc (750 mg elemental Ca). Fasting serum Zn levels were not different between patients and controls (14.0 +/- 2.3 v 14.1 +/- 1.2 mumol/L [91.8 +/- 14.9 v 92.3 +/- 8.0 micrograms/dL]), but the area under the curve of serum Zn increment (AUC) 2 hours after an oral Zn challenge without or with either of two of phosphate binders used was significantly smaller in patients than in controls (P less than 0.05). The AUC after concomitant administration of Zn with CaCO3 did not differ from that of Zn alone in either patients or controls, but it was significantly less in Zn with CaAc than in Zn alone or in Zn with CaCO3 in both groups. The results demonstrate that intestinal Zn absorption after an oral Zn challenge decreased in patients on hemodialysis and concomitant administration of CaAc, but CaCO3 did not decrease intestinal Zn absorption in either group.
由于氢氧化铝作为一种磷结合剂会降低肠道锌吸收，我们通过测量口服50毫克元素锌（以葡萄糖酸锌形式）且分别单独服用或同时服用2克碳酸钙（800毫克元素钙）或3克醋酸钙（750毫克元素钙）后1小时和2小时的血清锌水平，研究了另外两种磷结合剂碳酸钙（CaCO₃）和醋酸钙（CaAc）对9名血液透析患者和11名对照者肠道锌吸收的影响。患者和对照者的空腹血清锌水平无差异（14.0±2.3对14.1±1.2微摩尔/升[91.8±14.9对92.3±8.0微克/分升]），但在口服锌激发试验后，无论有无使用两种磷结合剂中的任何一种，患者2小时血清锌增量曲线下面积（AUC）均显著小于对照者（P＜0.05）。在患者和对照者中，锌与碳酸钙同时服用后的AUC与单独服用锌时无差异，但在两组中，锌与醋酸钙同时服用后的AUC显著低于单独服用锌或锌与碳酸钙同时服用时。结果表明，血液透析患者口服锌激发试验后肠道锌吸收降低，且同时服用醋酸钙会降低肠道锌吸收，但碳酸钙在两组中均未降低肠道锌吸收。
