Meas T, Mouly S, Kania R, Hervé D, Herman P, Kévorkian J P, Virally M, Laloi-Michelin M, Médeau V, Guillausseau P J
Department of Internal Medicine B, Lariboisière Hospital, APHP, 2, rue Ambroise-Paré, 75010 Paris, France.
Diabetes Metab. 2007 Jun;33(3):227-9. doi: 10.1016/j.diabet.2006.12.001. Epub 2007 Mar 27.
Mucormycosis is an emerging fungal infection with a high rate of mortality. Diabetic and immuno-compromised patients are the most frequent hosts. We report a case of rhino-orbito-cerebral mucormycosis revealed by facial palsy in a diabetic, immuno-compromised patient with difficult life conditions. He received intravenous antifungal treatment (amphotericin B) and early surgical debridement and completely recovered with no recurrence after 3 months of follow-up. Physicians should be aware of such atypical clinical presentations due to the need for early appropriate combined medical and surgical management to improve disease recovery and prognosis.
毛霉菌病是一种新出现的真菌感染,死亡率很高。糖尿病患者和免疫功能低下的患者是最常见的宿主。我们报告一例糖尿病、免疫功能低下且生活条件困难的患者,因面神经麻痹而被诊断为鼻眶脑毛霉菌病。他接受了静脉抗真菌治疗(两性霉素B)和早期手术清创,随访3个月后完全康复,无复发。由于需要早期进行适当的药物和手术联合治疗以改善疾病恢复和预后,医生应了解这种非典型临床表现。