Pfefferkorn E R
Med Biol. 1975 Oct;53(5):337-41.
The replication of both alpha- and picornaviruses results in the production of plus-stranded viral progeny. Each of these two classes of virus devotes about the same amount of viral genetic information to structural proteins but the alphaviruses use more genetic information for non-virion proteins. This additional information may be required because the alphaviruses have a much broader host range. Alternatively, the additional information may be required for interrupted transcription that yields a subgenomic mRNA that encodes all of the alphaviral structural proteins. This subgenomic mRNA allows preferential synthesis of a precursor af all virion proteins. Cleavage of this precursor has been observed during in vitro protein synthesis and can be prevented by an appropriate temperature-sensitive mutation.
甲型病毒和小核糖核酸病毒的复制都会产生正链病毒后代。这两类病毒用于结构蛋白的病毒遗传信息量大致相同，但甲型病毒将更多的遗传信息用于非病毒粒子蛋白。可能因为甲型病毒具有更广泛的宿主范围，所以需要这些额外的信息。或者，产生编码所有甲型病毒结构蛋白的亚基因组mRNA的间断转录可能需要这些额外信息。这种亚基因组mRNA允许优先合成所有病毒粒子蛋白的前体。在体外蛋白质合成过程中已观察到该前体的切割，并且可以通过适当的温度敏感突变来阻止。
