McIntire S L, Garriga G, White J, Jacobson D, Horvitz H R
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Neuron. 1992 Feb;8(2):307-22. doi: 10.1016/0896-6273(92)90297-q.
The outgrowth of single axons through different cellular environments requires distinct sets of genes in the nematode C. elegans. Three genes are required for the pioneering circumferential outgrowth of identified motor neuron axons between the lateral hypodermal cell membrane and the basal lamina. Three other genes are required for the longitudinal outgrowth of these axons along preexisting axon bundles as well as for the fasciculation of axons within these neuron bundles. Five additional genes are required for circumferential outgrowth, longitudinal outgrowth, and fasciculation; mutations in three of these genes disrupt axon ultrastructure, suggesting that they function in axon formation rather than in axon guidance.
在秀丽隐杆线虫中，单根轴突在不同细胞环境中的生长需要不同的基因组合。已确定的运动神经元轴突在外侧皮下细胞膜和基膜之间进行开拓性的圆周生长需要三个基因。这些轴突沿着预先存在的轴突束进行纵向生长以及这些神经元束内轴突的成束还需要另外三个基因。圆周生长、纵向生长和成束还需要另外五个基因；其中三个基因的突变会破坏轴突超微结构，这表明它们在轴突形成而非轴突导向中发挥作用。
