癌性结直肠组织中的表皮生长因子受体水平低于正常结直肠组织。
Epidermal growth factor receptor levels are lower in carcinomatous than in normal colorectal tissue.
作者信息
Koenders P G, Peters W H, Wobbes T, Beex L V, Nagengast F M, Benraad T J
机构信息
Department of Experimental and Chemical Endocrinology, University Hospital Nijmegen, The Netherlands.
出版信息
Br J Cancer. 1992 Feb;65(2):189-92. doi: 10.1038/bjc.1992.39.
A series of 24 paired samples of colorectal carcinoma and the respective normal colorectal mucosa were analysed for Epidermal Growth Factor Receptor (EGFR) content by means of a standardised ligand binding assay. We, for the first time, found that EGFR levels are statistically significantly higher in normal colorectal mucosa biopsy samples than they are in colorectal carcinoma biopsy samples, the median EGFR levels being 77.5 fmol mg-1 of membrane protein (range 35-239), against 46 fmol mg-1 of membrane protein (range 22-81), respectively, P less than 0.001. In addition, we found that there are significant regional differences in EGFR expression in the normal human colon mucosa. The EGFR levels were significantly higher in samples from the proximal part of the colon than they were in samples from the distal part, the median EGFR levels being 124 fmol mg-1 of membrane protein (range 70-239) vs 55 fmol mg-1 membrane protein (range 35-156), P less than 0.05. The EGFR levels of the colorectal carcinoma samples did not show any regional variation.
采用标准化配体结合分析法，对24对结直肠癌及相应的正常结直肠黏膜样本进行了表皮生长因子受体（EGFR）含量分析。我们首次发现，正常结直肠黏膜活检样本中的EGFR水平在统计学上显著高于结直肠癌活检样本，EGFR水平中位数分别为膜蛋白77.5 fmol mg-1（范围35 - 239）和膜蛋白46 fmol mg-1（范围22 - 81），P < 0.001。此外，我们发现正常人类结肠黏膜中EGFR表达存在显著的区域差异。结肠近端样本中的EGFR水平显著高于远端样本，EGFR水平中位数分别为膜蛋白124 fmol mg-1（范围70 - 239）和膜蛋白55 fmol mg-1（范围35 - 156），P < 0.05。结直肠癌样本的EGFR水平未显示出任何区域差异。
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