Zini Eric, Hauser Beat, Meli Marina L, Glaus Tony M
Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
J Am Vet Med Assoc. 2007 Apr 1;230(7):1024-7. doi: 10.2460/javma.230.7.1024.
A 6-month-old domestic shorthair cat was evaluated because of acute lethargy.
Severe nonregenerative anemia and thrombocytopenia were identified. Cytologic examination of a bone marrow aspirate revealed selective erythroid and mega-karyocytic aplasia and a high number of apparently normal small lymphocytes. Infectious agents implicated in feline hematologic disorders were excluded on the basis of serologic tests or PCR amplification, including FeLV, Ehrlichia canis, Anaplasma phagocytophilum, Mycoplasma haemofelis, Candidatus Mycoplasma haemominutum, and Candidatus Myco-plasma turicensis.
A 10-day course of prednisolone administration did not improve the hematologic disorder. Administration of human polyclonal immunoglobulins preceded increased reticulocyte count by 3 days. A second bone marrow examination confirmed restoration of erythroblasts and megakaryocytes. After 1 relapse, the disease was successfully controlled with prednisolone for > 3 years.
Immune-mediated bone marrow aplasia is rare in cats and usually affects only erythrocyte progenitors. Concomitant involvement of erythroid and megakaryocytic cell lines can be successfully treated via immunosuppressive therapy. Human immunoglobulins seem to be well tolerated in cats; however, proof of a beneficial effect requires further study.
一只6个月大的家养短毛猫因急性嗜睡接受评估。
确诊为严重的非再生性贫血和血小板减少症。骨髓穿刺液的细胞学检查显示选择性红系和巨核细胞发育不全，并有大量明显正常的小淋巴细胞。根据血清学检测或PCR扩增排除了与猫血液系统疾病相关的感染因子，包括猫白血病病毒（FeLV）、犬埃立克体、嗜吞噬细胞无形体、溶血支原体、微小支原体和图氏支原体。
泼尼松龙治疗10天并未改善血液系统疾病。给予人多克隆免疫球蛋白3天后网织红细胞计数增加。第二次骨髓检查证实有幼红细胞和巨核细胞恢复。在1次复发后，该疾病通过泼尼松龙成功控制超过3年。
免疫介导的骨髓发育不全在猫中罕见，通常仅影响红细胞祖细胞。红系和巨核细胞系同时受累可通过免疫抑制治疗成功治疗。人免疫球蛋白在猫中似乎耐受性良好；然而，其有益效果的证据需要进一步研究。
