Walton Aaron L, Howden Benjamin P, Grayson Lindsay M, Korman Tony M
Infectious Diseases Department, Monash Medical Centre, Clayton, Australia.
Int J Antimicrob Agents. 2007 May;29(5):544-8. doi: 10.1016/j.ijantimicag.2006.10.018. Epub 2007 Mar 29.
To evaluate the feasibility of continuous-infusion (CI) penicillin in the treatment of serious bacterial infections, consecutive adult patients with deep-seated infections due to penicillin-susceptible pathogens were treated with CI aqueous penicillin G in a home-based programme, and their treatment outcomes were reviewed. Thirty-one patients with microbiologically proven infections completed the planned course of treatment. Twenty of 31 (65%) were followed for at least 2 months thereafter, and all remained free of relapse. One patient had fever attributable to penicillin hypersensitivity, two patients developed catheter-site infections and one patient developed catheter-related bacteraemia. Thus, CI penicillin is feasible for the home-based treatment of a variety of deep-seated infections with minimal toxicity.
为评估持续输注（CI）青霉素治疗严重细菌感染的可行性，在一项居家治疗方案中，对因青霉素敏感病原体导致深部感染的成年患者连续给予CI青霉素G进行治疗，并对其治疗结果进行回顾性分析。31例经微生物学证实感染的患者完成了计划的治疗疗程。其中31例中的20例（65%）此后至少随访了2个月，且均未复发。1例患者出现青霉素过敏所致发热，2例患者发生导管部位感染，1例患者发生导管相关菌血症。因此，CI青霉素用于居家治疗各种深部感染且毒性极小是可行的。
