智能输液技术对抗凝剂（普通肝素、阿加曲班、比伐卢定和重组水蛭素）给药的影响。

Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin).

作者信息

Fanikos John, Fiumara Karen, Baroletti Steve, Luppi Carol, Saniuk Catherine, Mehta Amar, Silverman Jon, Goldhaber Samuel Z

机构信息

Department of Pharmacy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Am J Cardiol. 2007 Apr 1;99(7):1002-5. doi: 10.1016/j.amjcard.2006.10.069. Epub 2007 Feb 15.

DOI:10.1016/j.amjcard.2006.10.069

PMID:17398201

Abstract

This study reviewed 863 alerts generated from the infusion of anticoagulants in 355 patients from October 2003 to January 2005. Alerts were generated by smart infusion technology pumps and recorded in the devices' memory. The most common alerts were underdose alerts (59.8%), followed by overdose alerts (31.3%) and duplicate drug therapy alerts (8.9%). In response to the alerts, users' most frequent action was to cancel (46.5%) or reprogram (43.1%) the infusions. The highest percentage of alerts occurred from 2 to 4 p.m. During the study, there were 4 infusion rate errors, compared with 15 in the immediately preceding 16-month period. In conclusion, smart infusion technology intercepted keypad entry errors, thereby reducing the likelihood of intravenous anticoagulant overdose or underdose. Dose or infusion rate programming during intravenous anticoagulation is an important targets for medication safety interventions.

摘要

本研究回顾了2003年10月至2005年1月期间355例患者输注抗凝剂产生的863次警报。警报由智能输液技术泵生成，并记录在设备内存中。最常见的警报是剂量不足警报（59.8%），其次是过量警报（31.3%）和重复药物治疗警报（8.9%）。针对这些警报，用户最常采取的行动是取消（46.5%）或重新编程（43.1%）输液。最高比例的警报发生在下午2点至4点。在研究期间，有4次输液速率错误，而在前一个16个月期间有15次。总之，智能输液技术拦截了键盘输入错误，从而降低了静脉注射抗凝剂过量或不足的可能性。静脉抗凝期间的剂量或输液速率编程是药物安全干预的重要目标。