Lennartz H
MMW Munch Med Wochenschr. 1975 Nov 21;117(47):1871-4.
The demonstration of antibody titer movements in the hemagglutination inhibition test, in the complement fixation test and a differentiation between IgM and IgG antibodies allow information to be obtained on the age of an intra-uterine rubella infection. Specific IgM antibodies in neonates are reliable evidence, because the maternal IgM antibodies cannot cross the placenta. A rise in total IgM level in cord blood does not, on the other hand, indicate an embryopathy in every case. In contradistinction to rubella, cytomegaly and herpes simplex virus can be comparatively easily and quickly cultivated, so that identification of the virus is of use for clinical purposes. Of 2360 children investigated in our laboratory from 1969-1974, 120 certainly and 57 extremely probably showed rubella embryopathies.
在血凝抑制试验、补体结合试验中抗体滴度变化的测定以及IgM和IgG抗体之间的区分，能够获取有关子宫内风疹感染时间的信息。新生儿体内的特异性IgM抗体是可靠的证据，因为母体的IgM抗体无法穿过胎盘。另一方面，脐血中总IgM水平的升高并非在每种情况下都表明存在胚胎病变。与风疹不同，巨细胞病毒和单纯疱疹病毒相对容易且快速培养，因此病毒鉴定对临床有帮助。在我们实验室1969年至1974年调查的2360名儿童中，有120名肯定患有风疹胚胎病变，57名极有可能患有风疹胚胎病变。
