Andersson A P, Gottlieb J, Drzewiecki K T, Hou-Jensen K, Sondergaard K
Department of Reconstructive Surgery, University State Hospital, Copenhagen, Denmark.
Cancer. 1992 Mar 1;69(5):1153-6. doi: 10.1002/cncr.2820690515.
The clinicopathologic and therapeutic data of 512 patients, with clinical Stage I invasive head and neck melanoma of the skin were retrospectively evaluated. There were 287 females and 225 males. Median age at primary surgery was 65 years (range, 18 to 96 years). Median observation period was 5 years (range, 1 month to 25 years). Site of first recurrence was local in 7% (38 of 512), regional in 13% (67 of 512) and distant in 6% (31 of 512). Sex, age, ulcerated tumor, and tumor thickness were found to act as independent risk factors to recurrence-free survival by Cox multivariate regression analysis. In addition, size of excision margin was found to be of no significance to survival without relapse when adjusting for the independent risk factors.
对512例临床I期皮肤侵袭性头颈部黑色素瘤患者的临床病理及治疗数据进行了回顾性评估。其中女性287例，男性225例。初次手术时的中位年龄为65岁（范围18至96岁）。中位观察期为5年（范围1个月至25年）。首次复发部位为局部的占7%（512例中的38例），区域的占13%（512例中的67例），远处的占6%（512例中的31例）。通过Cox多因素回归分析发现，性别、年龄、溃疡型肿瘤及肿瘤厚度是无复发生存的独立危险因素。此外，在调整独立危险因素后，切缘大小对无复发生存无显著影响。
