Andersson A P, Gottlieb J, Søndergaard K, Hou-Jensen K, Drzewiecki K T
Kirurgisk afdeling S, rekonstruktionskirurgi og patologiafdelingen, Rigshospitalet, København.
Ugeskr Laeger. 1993 Aug 2;155(31):2397-9.
The clinico-pathological and therapeutic data of 512 patients with clinical stage I invasive head and neck melanoma of the skin were re-evaluated. There were 287 females and 225 males. The median age at primary surgery was 65 years, range 18 to 96 years. The median observation period was 5 years, range 1 month to 25 years. Sex, age, ulcerated tumor and tumor thickness were found by Cox multivariate regression analysis to act as independent prognostic factors for recurrence-free survival. In addition, size of the excision margin was found of no significance for survival without relapse when adjusting for the independent risk factors.
对512例临床I期皮肤侵袭性头颈部黑色素瘤患者的临床病理和治疗数据进行了重新评估。其中女性287例，男性225例。初次手术时的中位年龄为65岁，范围为18至96岁。中位观察期为5年，范围为1个月至25年。通过Cox多变量回归分析发现，性别、年龄、肿瘤溃疡和肿瘤厚度是无复发生存的独立预后因素。此外，在调整独立危险因素后，发现切缘大小对无复发生存无显著意义。
