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Four cardiac hormones eliminate 4-fold more human glioblastoma cells than the green mamba snake peptide.

作者信息

Vesely Brian A, Eichelbaum Ehrentraud J, Alli Abdel A, Sun Ying, Gower William R, Vesely David L

机构信息

Department of Internal Medicine, James A Haley Veterans Medical Center, Tampa, FL 33612, USA.

出版信息

Cancer Lett. 2007 Aug 28;254(1):94-101. doi: 10.1016/j.canlet.2007.02.015. Epub 2007 Mar 30.

DOI:10.1016/j.canlet.2007.02.015
PMID:17399891
Abstract

UNLABELLED

Within 24h four cardiac hormones, i.e., vessel dilator, kaliuretic peptide, atrial natriuretic peptide, and long acting natriuretic peptide decrease the number of human glioblastoma cells 75%, 68%, 67%, and 65% while Dendroaspis (green mamba) peptide caused a 17% decrease when each were utilized at 100 microM. The four cardiac hormones decreased DNA synthesis 65-87% and increased cyclic GMP 1.3- to 3.8-fold in the glioblastoma cells. Natriuretic peptide receptors (NPR)-A and -C were present.

CONCLUSION

four cardiac hormones eliminate up to 75% of glioblastoma cells via cyclic GMP-mediated up to 87% decrease in DNA synthesis.

摘要

相似文献

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