Migrino Raymond Q, Zhu Xiaoguang, Pajewski Nicholas, Brahmbhatt Tejas, Hoffmann Raymond, Zhao Ming
Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
J Am Soc Echocardiogr. 2007 Apr;20(4):342-51. doi: 10.1016/j.echo.2006.09.011.
We determined whether 2-dimensional strain echocardiography can identify viable from infarcted myocardium in a rat ischemia-reperfusion model. A total of 16 male Sprague-Dawley rats underwent left anterior descending coronary artery occlusion for 12 or 30 minutes followed by 60-minute reperfusion. Short-axis 2-dimensional strain echocardiography was performed at the mid-ventricle 60 minutes post-reperfusion. Post-sacrifice, triphenyl tetrazolium chloride was infused to the coronary circulation. Regional end-systolic radial and circumferential strain, and time to peak strain, were measured using software in all 96 segments and correlated with areas of infarct in corresponding histologic slices. Segments with greater than 50% area of infarct had lower end-systolic radial and circumferential strain and longer time to peak strain versus areas with 50% or less strain or no infarct. Extent of infarct correlates with radial and circumferential strain. End-systolic radial strain less than 2% has 88% sensitivity and 95% specificity for detecting infarcted area greater than 50%. Two-dimensional strain echocardiography-derived strain is useful in distinguishing infarcted from viable myocardium.
我们确定二维应变超声心动图能否在大鼠缺血再灌注模型中鉴别梗死心肌与存活心肌。总共16只雄性Sprague-Dawley大鼠接受左前降支冠状动脉闭塞12或30分钟，随后再灌注60分钟。在再灌注60分钟后于心室中部进行短轴二维应变超声心动图检查。处死后，将氯化三苯基四氮唑注入冠状动脉循环。使用软件测量所有96个节段的区域收缩末期径向应变和圆周应变以及应变峰值时间，并与相应组织学切片中的梗死面积相关联。梗死面积大于50%的节段与梗死面积为50%或更小或无梗死的区域相比，收缩末期径向应变和圆周应变更低，应变峰值时间更长。梗死范围与径向应变和圆周应变相关。收缩末期径向应变小于2%对检测梗死面积大于50%具有88%的敏感性和95%的特异性。二维应变超声心动图得出的应变有助于区分梗死心肌与存活心肌。
