Sánchez-Madrid Francisco, Serrador Juan M
Departamento de Biología Vascular e Inflamación, Centro Nacional de Investigaciones Cardiovasculares, 28029 Madrid, Spain.
Trends Immunol. 2007 May;28(5):193-6. doi: 10.1016/j.it.2007.03.007. Epub 2007 Apr 2.
Leukocyte polarization and chemotaxis have a key role in the homeostasis of the immune system and in inflammation. Recent work shows that chemoattractants induce the redistribution of mitochondria towards the uropod of polarized migrating leukocytes through a mechanism involving microtubules and mitochondrial fission. These findings underscore the key role this organelle can have in leukocyte chemotaxis by fuelling motor proteins at their trailing edge.
白细胞极化和趋化作用在免疫系统的稳态及炎症过程中起着关键作用。最近的研究表明，趋化因子通过一种涉及微管和线粒体分裂的机制，诱导线粒体重新分布至极化迁移白细胞的尾足。这些发现强调了该细胞器通过为运动蛋白在其 trailing edge 提供能量，在白细胞趋化作用中可能发挥的关键作用。 （注：trailing edge 直译为“后缘”，结合语境这里应该是指细胞移动时后方的边缘部分，专业语境中可能有更准确术语，但按要求未添加额外解释）
