Dettmar P
Neirofiziologiia. 1975;7(1):48-54.
Acetylcholine applied to the isolated perfused retina (frog and man) elicits a slow corneapositive potential. Such an effect of ACh besides the data known from the literature confirms an assumption on cholinergic synaptic transmission within the retina. The retinal potential elicited by ACh depends in its size and time course on definite parameters of the ACh application as well as on the illumination state of the retina: light stimulation diminishes the electrogenic action of ACh, flickering illumination being more effective than steady one. On the other hand electrical responsiveness of the retina to light lowered during the perfusion of the preparation with ACh. The b-wave seems to be the most sensitive part of the ERG and can be abolished completely, thus isolating the component PIII. The mentioned results as well as the data from the literature indicate the synapses between the first and second retinal neurons as the points of ACh action. Experimental results can be interpreted as the consequence of a desensitization of the cholinergic receptors within the retina.
将乙酰胆碱应用于离体灌注视网膜（青蛙和人类）会引发缓慢的角膜正电位。除了文献中已知的数据外，乙酰胆碱的这种作用证实了关于视网膜内胆碱能突触传递的一种假设。乙酰胆碱引发的视网膜电位在其大小和时间进程上取决于乙酰胆碱应用的特定参数以及视网膜的光照状态：光刺激会减弱乙酰胆碱的电生成作用，闪烁光照比稳定光照更有效。另一方面，在用乙酰胆碱灌注标本期间，视网膜对光的电反应性降低。b波似乎是视网膜电图中最敏感的部分，并且可以完全消除，从而分离出PIII成分。上述结果以及文献数据表明，第一和第二视网膜神经元之间的突触是乙酰胆碱的作用点。实验结果可以解释为视网膜内胆碱能受体脱敏的结果。
