Veerman Krystle M, Williams Michael J, Uchimura Kenji, Singer Mark S, Merzaban Jasmeen S, Naus Silvia, Carlow Douglas A, Owen Philip, Rivera-Nieves Jesús, Rosen Steven D, Ziltener Hermann J
The Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Nat Immunol. 2007 May;8(5):532-9. doi: 10.1038/ni1456. Epub 2007 Apr 1.
P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. Here we show that PSGL-1 was also required for efficient homing of resting T cells to secondary lymphoid organs but functioned independently of selectin binding. PSGL-1 mediated an enhanced chemotactic T cell response to the secondary lymphoid organ chemokines CCL21 and CCL19 but not to CXCL12 or to inflammatory chemokines. Our data show involvement of PSGL-1 in facilitating the entry of T cells into secondary lymphoid organs, thereby demonstrating the bifunctional nature of this molecule.
P-选择素糖蛋白配体1（PSGL-1）通过与P-选择素、E-选择素和L-选择素的直接相互作用，在免疫效应细胞向炎症区域的运输过程中起着核心作用。在此我们表明，静止T细胞向次级淋巴器官的有效归巢也需要PSGL-1，但它的功能独立于选择素结合。PSGL-1介导T细胞对次级淋巴器官趋化因子CCL21和CCL19的趋化反应增强，但对CXCL12或炎症趋化因子无此反应。我们的数据表明PSGL-1参与促进T细胞进入次级淋巴器官，从而证明了该分子的双功能性质。
