纳洛酮和纳曲酮对雌性大鼠接受性行为和主动性行为的影响。

Effects of naloxone and naltrexone on receptive and proceptive behaviors in female rats.

作者信息

Saito T R, Aoki S, Hokao R, Amao H, Wakafuji Y, Sugiyama M, Takahashi K W

机构信息

Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.

出版信息

Jikken Dobutsu. 1992 Jan;41(1):75-7. doi: 10.1538/expanim1978.41.1_75.

DOI:10.1538/expanim1978.41.1_75

PMID:1740170

Abstract

The sexual receptive and proceptive behaviors induced by opiate antagonists, naloxone and naltrexone in estrogen-primed ovariectomized rats were observed under the presence of sexually active males. The females were treated intraperitoneally with naloxone or naltrexone at doses ranging from 0.5 to 4.0 mg/kg and the sexual behavior of females was tested before and after the injection of drug. The results obtained suggest that the opiate antagonists play a role in the regulation of lordosis behavior, but not proceptive behavior in female rats.

摘要

在有性活跃雄性大鼠存在的情况下，观察了阿片类拮抗剂纳洛酮和纳曲酮在雌激素预处理的去卵巢大鼠中诱导的性接受和性前行为。雌性大鼠腹腔注射剂量范围为0.5至4.0mg/kg的纳洛酮或纳曲酮，并在注射药物前后测试雌性大鼠的性行为。所得结果表明，阿片类拮抗剂在雌性大鼠的脊柱前凸行为调节中起作用，但在性前行为调节中不起作用。