大鼠垂体切除术后活动及饮水节律的变化
Changes in rhythmicities of ambulatory and drinking activities after hypophysectomy in rats.
作者信息
Shinoda M, Miura T, Tadokoro S
机构信息
Institute of Experimental Animal Research, Gunma University School of Medicine, Japan.
出版信息
Jikken Dobutsu. 1992 Jan;41(1):93-9. doi: 10.1538/expanim1978.41.1_93.
Effects of hypophysectomy on circadian rhythms of ambulatory and drinking activities in adult male rats were automatically recorded and investigated with a Gundai-type ambulodrinkometer. The rats were maintained under LL conditions following an LD condition. When free-running rhythms had stabilized, the rats were hypophysectomized. The rhythmicities of both activities became indistinct over the 2-4 weeks following surgery, and then gradually recovered. At this time phase shifts (phase advance) were observed in the hypophysectomized rats, while these changes were not observed in sham-operated rats. All rats entrained to lighting when kept under LD conditions again. These results suggest that the pituitary does not play an essential role in maintaining circadian rhythms, but does function as an important subordinal oscillator.
采用Gundai型活动-饮水记录器自动记录并研究了垂体切除对成年雄性大鼠活动和饮水昼夜节律的影响。大鼠先在LD条件下饲养，然后置于LL条件下。当自由活动节律稳定后，对大鼠进行垂体切除。术后2-4周内，两种活动的节律性均变得不明显，随后逐渐恢复。此时，垂体切除的大鼠出现了相位移动（相位提前），而假手术大鼠未观察到这些变化。再次将所有大鼠置于LD条件下时，它们均能与光照同步。这些结果表明，垂体在维持昼夜节律方面并非起着必不可少的作用，但却是一个重要的从属振荡器。
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