125I粒子植入联合区域动脉灌注化疗治疗晚期胰腺癌
[Treatment of late-staged pancreatic carcinoma with implantation of 125I seeds in combination with regional arterial infusion chemotherapy].
作者信息
Ai Kai-xing, Zheng Qi, Xia Yang, Huang Xin-yu, Zou Jian-hua, Yan Jun, Mao Jiang-yong
机构信息
Department of Hepatobiliary and Pancreatic Surgery, No.6 People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2007 Jan 1;45(1):27-9.
OBJECTIVE
To evaluate the effect of combined use of implantation of (125)I seeds with regional arterial infusion chemotherapy on late-staged pancreatic carcinoma.
METHODS
During operation, (125)I seeds were implanted into tumor parenchyma or operative beds for 7 patients with pathological diagnosis of late-staged pancreatic carcinoma, then chemotherapy pump was implanted into common hepatic artery or celiac artery through left gastric artery or right epigastric artery. Gemcitabine (1000 mg/m(2)) plus fluorouracil (500 mg/m(2)) was used for postoperative adjuvant chemotherapy once a week for 7 consecutive weeks.
RESULTS
The mean number of implanted (125)I seeds was 42 and the mean dose was 29.4 mCi. The mean follow-up time was 245 days. Rate of pain relief was 100%, metastasis foci was reduced in 2 cases. CA-19-9 Antigen level decreased to normal in all patients. Pancreatic fistula occurred in one case and was cured with conservative therapy.
CONCLUSIONS
The combination therapy is effective for late-staged pancreatic carcinoma, it brings symptom relief and improvement in quality of life.
目的
评估¹²⁵I粒子植入联合区域动脉灌注化疗对晚期胰腺癌的疗效。
方法
手术中，对7例病理诊断为晚期胰腺癌的患者，将¹²⁵I粒子植入肿瘤实质或手术床，然后通过胃左动脉或右腹壁动脉将化疗泵植入肝总动脉或腹腔动脉。采用吉西他滨（1000mg/m²）加氟尿嘧啶（500mg/m²）进行术后辅助化疗，每周1次，连续7周。
结果
¹²⁵I粒子平均植入数量为42粒，平均剂量为29.4mCi。平均随访时间为245天。疼痛缓解率为100%，2例转移灶缩小。所有患者CA-19-9抗原水平均降至正常。1例发生胰瘘，经保守治疗治愈。
结论
联合治疗对晚期胰腺癌有效，可缓解症状，提高生活质量。
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