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[溃疡性结肠炎与血小板减少症:偶然关联的临床病例?]

[Ulcerative colitis and thrombocytopenia: a clinical case of fortuitous association?].

作者信息

Braucci S, Trappolini F, Angrisani L, Luberti E, Clarice A, Proietta M, Pisani D, Trappolini M

机构信息

Dipartimento di Medicina Interna, Ospedale Sant'Andrea, II Facoltui di Medicina, Università di Roma La Sapienza, Roma, Italia.

出版信息

Clin Ter. 2007 Jan-Feb;158(1):27-30.

Abstract

Ulcerative colitis (UC) is an inflammatory bowel disease of unknown etiology, involving primarily the rectum with major intestinal symptoms. Additionally, UC is often associated with extraintestinal manifestations, especially arthropathies, as well as with some autoimmune disorders. Vice versa, UC is rarely described in association with hematologic abnormalities, such as autoimmune hemolytic anemia and immune thrombocytopenic purpura with antiplatelet antibodies positive. Usually UC precedes the onset of thrombocytopenia by days or years or coincides with it. We report a case of UC and thrombocytopenia with negative anti-platelet antibodies in which an immunosuppressive therapy with corticosteroids obtained significant remission of intestinal symptoms along with a rapid increase of platelet count.

摘要

溃疡性结肠炎(UC)是一种病因不明的炎症性肠病,主要累及直肠并伴有主要的肠道症状。此外,UC常与肠外表现相关,尤其是关节病,以及一些自身免疫性疾病。反之,UC很少与血液学异常相关,如自身免疫性溶血性贫血和抗血小板抗体阳性的免疫性血小板减少性紫癜。通常UC在血小板减少症发作前数天或数年出现,或与之同时出现。我们报告一例UC合并血小板减少症且抗血小板抗体阴性的病例,其中使用皮质类固醇进行免疫抑制治疗使肠道症状显著缓解,同时血小板计数迅速增加。

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