手性席夫碱-锌配合物催化1-乙炔基环己烯对芳香族和杂芳香族酮的不对称加成反应。

Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base-zinc complex.

作者信息

Wang Quan, Zhang Bangzhi, Hu Guowen, Chen Chao, Zhao Qinyang, Wang Rui

机构信息

Department of Biochemistry and Molecular Biology, School of Life Sciences, and State key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China.

出版信息

Org Biomol Chem. 2007 Apr 21;5(8):1161-3. doi: 10.1039/b702069d. Epub 2007 Mar 9.

DOI:10.1039/b702069d

PMID:17406711

Abstract

The evaluation of a chiral Schiff base ligand in the zinc-catalyzed asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones is reported (with up to 83% enantioselectivity and up to 88% isolated yield).

摘要

本文报道了一种手性席夫碱配体在锌催化的1-乙炔基环己烯与芳香族和杂芳香族酮的不对称加成反应中的评估（对映选择性高达83%，分离产率高达88%）。