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镍催化的炔烃与醛的对映选择性烷基化偶联反应：合成具有四取代烯烃的手性烯丙醇

Nickel-catalyzed enantioselective alkylative coupling of alkynes and aldehydes: synthesis of chiral allylic alcohols with tetrasubstituted olefins.

作者信息

Yang Yun, Zhu Shou-Fei, Zhou Chang-Yue, Zhou Qi-Lin

机构信息

State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.

出版信息

J Am Chem Soc. 2008 Oct 29;130(43):14052-3. doi: 10.1021/ja805296k. Epub 2008 Oct 4.

DOI:10.1021/ja805296k
PMID:18834121
Abstract

A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc has been realized by using bulky spirobiindane phosphoramidite ligands, affording allylic alcohols with a tetrasubstituted olefin functionality in high yields, high regioselectivities, and excellent enantioselectivities.

摘要

通过使用庞大的螺双茚满亚磷酰胺配体，实现了镍催化的炔烃、醛和二甲基锌的高效不对称烷基化偶联反应，以高收率、高区域选择性和优异的对映选择性得到具有四取代烯烃官能团的烯丙醇。

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