Zhu Xiao-bin, Li Zhen, Guo An-liang, Cao Xiao-rong, Liu Yong, Gong Dong-ming, Wang Yi-xin
Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Apr;24(2):203-5.
To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.
The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.
Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.
AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.
分析不育男性家系中的Y染色体微缺失情况，并研究Y染色体微缺失从父亲到儿子的垂直传递。
提取不育患者家系男性成员的外周血，采用改良多重聚合酶链反应进行分析。根据结果绘制不育家系图谱。
在12个被调查的家系中，有2例存在无精子症因子（AZFc）微缺失遗传现象，其他家系无此遗传现象。
Y染色体的AZFc微缺失可自然传递给男性后代，且相同的缺失在不同个体中可导致不同的表型。
