Höybye Charlotte
Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden.
Acta Paediatr. 2007 Mar;96(3):410-3. doi: 10.1111/j.1651-2227.2006.00051.x.
We have previously shown that 1 year of growth hormone (GH) treatment to adults with Prader-Willi syndrome (PWS) has beneficial effects on body composition. The aim of the present observational study was to re-evaluate our cohort, with focus on long-term GH treatment.
Seven men and seven women, median age 31 years, were available for follow-up for 6 years. Nine were on GH treatment for 5 years. Body composition was measured with Dual Energy X-ray absorptiometry (DXA).
In six GH treated patients with genetically verified PWS there was a substantial increase in lean body mass of 5 kg (p = 0.031) and a concomitant, however, non-significant, decrease in body fat of 5% (p = 0.156). The changes in the genetically verified patients without GH treatment were small and unsystematic. No compliance problems were reported. Only one non-GH-treated woman developed overt diabetes.
Despite inherent behavioural problems it was possible to continue GH injections for 5 years with sustained favourable effects on body composition without clinically, significant side effects.
我们之前已表明，对普拉德-威利综合征（PWS）成人患者进行1年的生长激素（GH）治疗对身体成分有有益影响。本观察性研究的目的是重新评估我们的队列，重点关注长期GH治疗。
7名男性和7名女性，中位年龄31岁，可进行6年的随访。其中9人接受了5年的GH治疗。采用双能X线吸收法（DXA）测量身体成分。
在6例经基因验证的接受GH治疗的PWS患者中，去脂体重显著增加5千克（p = 0.031），然而，体脂同时下降5%，但差异无统计学意义（p = 0.156）。未经GH治疗的经基因验证患者的变化较小且无系统性规律。未报告依从性问题。只有1名未接受GH治疗的女性患明显糖尿病。
尽管存在固有的行为问题，但仍有可能持续进行5年的GH注射，对身体成分持续产生有利影响，且无临床显著副作用。
