作为基于二糖模拟物的人β-葡萄糖脑苷脂酶抑制剂的4-O-糖基化1-脱氧野尻霉素衍生物的合成
Synthesis of 4-O-glycosylated 1-deoxynojirimycin derivatives as disaccharide mimics-based inhibitors of human beta-glucocerebrosidase.
作者信息
Boucheron Charlotte, Toumieux Sylvestre, Compain Philippe, Martin Olivier R, Ikeda Kyoko, Asano Naoki
机构信息
Institut de Chimie Organique et Analytique, CNRS-Université d'Orléans, rue de Chartres, BP 6759, 45067 Orléans, France.
出版信息
Carbohydr Res. 2007 Sep 3;342(12-13):1960-5. doi: 10.1016/j.carres.2007.03.015. Epub 2007 Mar 16.
PMID:17407774
Abstract
Examples of a new type of inhibitor of human beta-glucocerebrosidase based on imino-disaccharides as glycosylceramide mimetics have been synthesized by way of the glycosylation of 1-deoxynojirimycin derivatives with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide.
摘要
基于亚氨基二糖作为糖基神经酰胺模拟物的新型人β-葡萄糖脑苷脂酶抑制剂的实例，已通过1-脱氧野尻霉素衍生物与2,3,4,6-四-O-乙酰基-α-D-吡喃葡萄糖基溴的糖基化反应合成。
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