芪类低聚物对耐万古霉素肠球菌（VRE）和耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性及其与抗生素的协同作用。

Antibacterial activity of stilbene oligomers against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) and their synergism with antibiotics.

作者信息

Sakagami Yoshikazu, Sawabe Akiyoshi, Komemushi Sadao, All Zulfiqar, Tanaka Toshiyuki, Iliya Ibrahim, Iinuma Munekazu

机构信息

Kinki University, Faculty of Agriculture, 3327-204 Nakamachi, Nara-shi, Nara 631-8505, Japan.

出版信息

Biocontrol Sci. 2007 Mar;12(1):7-14. doi: 10.4265/bio.12.7.

DOI:10.4265/bio.12.7

PMID:17408003

Abstract

Two resveratrol trimers, gnemonol B isolated from Gnetum gnemon and gnetin E obtained from the Gnetum species, were found to exhibit strong antibacterial activities against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). The MIC values of gnemonol B against five strains of VRE and nine strains of MRSA were 12.5 and 6.25 microg/ml, respectively. The MIC values of gnetin E against five strains of VRE and nine strains of MRSA ranged from 12.5 to 25microg/ml. These compounds also showed synergistic effects when used in combination with commercially available antibiotics according to the evaluation method using FIC indices. These findings suggested that the application of the test compounds alone or in combination with antibiotics might be useful in controlling and treating VRE and MRSA infections

摘要

从买麻藤中分离得到的两种白藜芦醇三聚体，即买麻藤醇B和从买麻藤属植物中获得的买麻藤素E，被发现对耐万古霉素肠球菌（VRE）和耐甲氧西林金黄色葡萄球菌（MRSA）具有很强的抗菌活性。买麻藤醇B对五株VRE和九株MRSA的最低抑菌浓度（MIC）值分别为12.5和6.25微克/毫升。买麻藤素E对五株VRE和九株MRSA的MIC值范围为12.5至25微克/毫升。根据使用FIC指数的评估方法，这些化合物与市售抗生素联合使用时也显示出协同作用。这些发现表明，单独使用或与抗生素联合使用测试化合物可能有助于控制和治疗VRE和MRSA感染。