Bade Steffen, Frey Andreas
Research Center Borstel, Division of Mucosal Immunology, Borstel, Germany.
Expert Rev Vaccines. 2007 Apr;6(2):153-68. doi: 10.1586/14760584.6.2.153.
Transmissible spongiform encephalopathies are fatal neurodegenerative disorders that affect humans and certain animals and are caused by prions. In most cases, infection occurs by ingestion of prions. Their long-time persistence in the environment creates a reservoir of potentially infectious matter that renders the eradication of the disease problematic. Unfortunately, no cure is available to date. Yet, for both the treatment of infected and the protection of uninfected individuals, active and passive immunizations have been shown to have a beneficial effect on the course of the disease. The current review provides an overview of such antibody-based approaches and assesses their feasibility and potential in prophylaxis and therapy of transmissible spongiform encephalopathies.
传染性海绵状脑病是一种致命的神经退行性疾病，会影响人类和某些动物，由朊病毒引起。在大多数情况下，感染是通过摄入朊病毒发生的。它们在环境中的长期存在形成了一个潜在传染源库，使得根除该疾病成为难题。不幸的是，迄今为止尚无治愈方法。然而，对于感染个体的治疗和未感染个体的保护而言，主动免疫和被动免疫已被证明对疾病进程有有益影响。本综述概述了此类基于抗体的方法，并评估了它们在传染性海绵状脑病预防和治疗中的可行性及潜力。
