术中热灌注化疗（HIPEC）期间奥沙利铂汽化对手术人员污染风险的评估。
Evaluation of the risk of contamination of surgical personnel by vaporization of oxaliplatin during the intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC).
作者信息
Guerbet M, Goullé J P, Lubrano J
机构信息
Laboratory of Toxicology, ADEN EA 3234, Rouen University Faculty of Medicine and Pharmacy, 22 boulevard Gambetta, 76183, Rouen cedex, France.
出版信息
Eur J Surg Oncol. 2007 Jun;33(5):623-6. doi: 10.1016/j.ejso.2007.02.027. Epub 2007 Apr 3.
AIMS
To evaluate if oxaliplatin is likely to vaporize under HIPEC conditions and to see if it could be a source of pulmonary contamination for surgeons.
METHODS
Three oxaliplatin concentrations (230, 460 and 920 mg oxaliplatin/l), 3 heating temperatures (41, 43 and 45 degrees C) and 3 bubbling durations (30, 60 and 90 min) were tested. Drug vaporization was evaluated by using inductively coupled plasma mass spectrometry (ICP-MS) to analyze platinum concentrations in the trap solutions.
RESULTS
At all concentrations of oxaliplatin solutions, heating temperatures and bubbling trap periods, the quantities of vaporized platinum were always insignificantly lower than 1 microg/l.
CONCLUSIONS
The experimental risk of pulmonary contamination of hospital staff during HIPEC procedure appears to be negligible. However a monitoring study with an analysis of samples of the operating theatre and urine from surgical personnel should be carried out to confirm these conclusions.
目的
评估奥沙利铂在腹腔热灌注化疗（HIPEC）条件下是否可能汽化，以及它是否会成为外科医生肺部污染的来源。
方法
测试了三种奥沙利铂浓度（230、460和920毫克奥沙利铂/升）、三种加热温度（41、43和45摄氏度）和三种鼓泡持续时间（30、60和90分钟）。通过电感耦合等离子体质谱法（ICP-MS）分析捕集溶液中的铂浓度来评估药物汽化情况。
结果
在所有奥沙利铂溶液浓度、加热温度和鼓泡捕集时间段下，汽化铂的量始终显著低于1微克/升。
结论
在HIPEC手术过程中医院工作人员肺部污染的实验风险似乎可以忽略不计。然而，应该进行一项监测研究，分析手术室样本和手术人员的尿液，以证实这些结论。
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