Sato Kanji, Ohmori Teppei, Shiratori Keiko, Yamazaki Kazuko, Yamada Emiko, Kimura Hironari, Takano Kazue
Institute of Clinical Endocrinology, Tokyo Women's Medical University, Tokyo, Japan.
Intern Med. 2007;46(7):391-5. doi: 10.2169/internalmedicine.46.1899. Epub 2007 Apr 2.
Iodine-induced hypothyroidism that develops in patients who gargle routinely with povidone iodine is well known. Usually the hypothyroidism is mild and resolves spontaneously upon cessation of gargling. Here, we report a 63-year-old patient with overt hypothyroidism that developed due to habitual gargling with povidone iodine for more than 10 years. The urinary excretion of iodine was estimated to be greater than 5 mg/day, based on values obtained from 18 normal subjects who gargled three times a day (4.6+/-2.1 mg, mean+/-SD). After discontinuation of the gargling, the patient has been euthyroid for more than 10 months.
长期使用聚维酮碘漱口的患者发生碘致甲状腺功能减退已为人熟知。通常这种甲状腺功能减退较为轻微，在停止漱口后可自行缓解。在此，我们报告一名63岁的患者，因长期使用聚维酮碘漱口超过10年而出现明显的甲状腺功能减退。根据18名每天漱口3次的正常受试者的数值（4.6±2.1mg，均值±标准差）估算，该患者碘的尿排泄量大于5mg/天。停止漱口后，该患者甲状腺功能正常已超过10个月。
