Mallik A A, Katchy K C, Clotan N
Department of Pathology, Al-Sabah Hospital, Safat, Kuwait.
Med Princ Pract. 2007;16(3):226-9. doi: 10.1159/000100395.
We report a case of plasma cell variant of Castleman's disease confined to the meninges.
A 53-year-old woman presented with severe headache lasting a few months, which was insidious in onset but followed a progressive course with associated vomiting, blurring of vision and diplopia. Investigations revealed a dural-based mass that was considered both radiologically and intraoperatively as a meningioma. Total surgical excision of the mass was performed. Histologically, it was a plasma cell variant of Castleman's disease with kappa light chain restriction. Laboratory investigations and whole body computerized tomography scan showed no significant abnormality. A short course of local radiotherapy was given. The patient is well 2 years after treatment.
This report highlights the rarity of solitary intracranial Castleman's disease and the difficulty in radiological and intraoperative diagnosis.
我们报告一例局限于脑膜的Castleman病浆细胞变异型病例。
一名53岁女性出现严重头痛，持续数月，起病隐匿，但呈进行性发展，伴有呕吐、视力模糊和复视。检查发现一个硬膜下肿块，影像学和术中均考虑为脑膜瘤。对该肿块进行了全切除手术。组织学检查显示为Castleman病浆细胞变异型，κ轻链受限。实验室检查和全身计算机断层扫描未发现明显异常。给予了短疗程的局部放疗。治疗后2年患者情况良好。
本报告强调了孤立性颅内Castleman病的罕见性以及影像学和术中诊断的困难。
