Papadimitrakopoulou Vassiliki, Adjei Alex A
MD Anderson Cancer Center, Houston, Texas 77030, USA.
J Thorac Oncol. 2006 Sep;1(7):749-51.
Aberrant intracellular signaling resulting from mutations and oncogenic activation, as well as gene amplification of critical proteins involved in signal transduction pathways, are key features of lung cancer. Three important intracellular signaling proteins, the mammalian target of rapamycin, protein kinase B, and mitogen-activated protein kinase kinase have emerged as attractive targets for lung cancer therapy. We review current information on the therapeutic manipulation of these targets and describe early clinical data in lung cancer.
由突变和致癌激活导致的异常细胞内信号传导，以及信号转导途径中关键蛋白的基因扩增，是肺癌的关键特征。三种重要的细胞内信号蛋白，即雷帕霉素的哺乳动物靶点、蛋白激酶B和丝裂原活化蛋白激酶激酶，已成为肺癌治疗的有吸引力的靶点。我们综述了关于这些靶点治疗性操作的当前信息，并描述了肺癌的早期临床数据。
