Wislez Marie, Beer David G, Wistuba Ignacio, Cadranel Jacques, Saijo Nagahiro, Johnson Bruce E
Service de Pneumologie et de Réanimation Respiratoire, AP-HP, Hôpital Tenon and Laboratoire de Biologie Cellulaire et d'Immunopathologie Pulmonaire, Université Paris VI, Paris, France.
J Thorac Oncol. 2006 Nov;1(9 Suppl):S8-12.
The charge of the Molecular Biology, Genomics, and Proteomics in Bronchioloalveolar Carcinoma Committee was to evaluate the molecular biology, genomic changes, and proteomic findings in patients with bronchioloalveolar carcinoma compared with other types of lung cancer. The literature was reviewed and unpublished information was presented by the committee members at the session. The molecular biology studies have included findings on epidermal growth factor receptor (EGFR) mutations, p53 mutations, K-ras mutations, and loss of heterozygosity. The genomic changes have mostly focused on the mRNA expression arrays as well as protein studies. The current state of knowledge was reviewed, the missing information was acknowledged, and proposals for future research were identified.
细支气管肺泡癌分子生物学、基因组学和蛋白质组学委员会的职责是评估细支气管肺泡癌患者与其他类型肺癌患者相比的分子生物学、基因组变化和蛋白质组学研究结果。委员会成员在会议上回顾了相关文献并提交了未发表的信息。分子生物学研究包括表皮生长因子受体（EGFR）突变、p53突变、K-ras突变和杂合性缺失的研究结果。基因组变化主要集中在mRNA表达阵列以及蛋白质研究上。会议对当前的知识状况进行了回顾，承认了存在的信息缺失，并确定了未来研究的建议。
