刺猬信号通路与肺癌
Hedgehog signaling pathway and lung cancer.
作者信息
Velcheti Vamsidhar, Govindan Ramaswamy
机构信息
Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
J Thorac Oncol. 2007 Jan;2(1):7-10. doi: 10.1097/JTO.0b013e31802c0276.
PMID:17410003
Abstract
Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and its potential role in the development of lung cancer.
摘要
负责胚胎发育的信号通路在成体干细胞维持及细胞对损伤的反应中起关键作用。成体稳态期间发育信号通路功能失调会导致各种事件，进而引发肿瘤形成。我们综述了刺猬信号通路的生物学特性及其在肺癌发生中的潜在作用。
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