Shimatani Tomohiko, Kuroiwa Tomoko, Moriwaki Mutsuko, Xu Jing, Tazuma Susumu, Inoue Masaki
Department of General Medicine, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Dig Dis Sci. 2007 Oct;52(10):2826-32. doi: 10.1007/s10620-006-9643-x. Epub 2007 Apr 5.
To achieve more potent and long-lasting acid suppression, omeprazole was administered for 7 days in 5 regimens: 10, 20, and 40 mg once daily (od), and 10 and 20 mg twice daily (bid), in 7 healthy Helicobacter pylori-negative CYP2C19 homozygous extensive metabolizers, and intragastric pH was continuously measured. The median intragastric pH and percent time pH > 4.0 for 24 hours increased dose dependently with 10, 20, and 40 mg od. Ten and 20 mg bid wre comparable to 20 and 40 mg od, respectively. Concerning percent time pH > 4.0 in the nighttime (20:00-8:00 hours), 20 mg bid was significantly superior to 40 mg od (P < .05). In 4 of the 5 regimens, all 7 subjects had nocturnal acid breakthrough, whereas with 20 mg bid it occurred in only 3. We concluded that, considering nighttime acid suppression, omeprazole 20 mg bid had the strongest effect.
为实现更强效、持久的抑酸效果，对7名健康的细胞色素P450 2C19纯合子广泛代谢者采用5种方案给予奥美拉唑治疗7天：每日1次（od）10、20和40毫克，以及每日2次（bid）10和20毫克，并持续测量胃内pH值。胃内pH值中位数以及24小时内pH>4.0的时间百分比随每日1次10、20和40毫克剂量增加而呈剂量依赖性升高。每日2次10和20毫克分别与每日1次20和40毫克相当。关于夜间（20:00 - 8:00时）pH>4.0的时间百分比，每日2次20毫克显著优于每日1次40毫克（P <.05）。在5种方案中的4种里，所有7名受试者均出现夜间酸突破，而每日2次20毫克方案中仅3人出现。我们得出结论，考虑到夜间抑酸效果，每日2次20毫克奥美拉唑效果最强。
