血小板内皮细胞黏附分子-1：巨核细胞生成的多面调节因子
PECAM-1: a multifaceted regulator of megakaryocytopoiesis.
作者信息
Wu Yue, Welte Thomas, Michaud Michael, Madri Joseph A
机构信息
Department of Pathology, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, USA.
出版信息
Blood. 2007 Aug 1;110(3):851-9. doi: 10.1182/blood-2006-05-022087. Epub 2007 Apr 5.
PECAM-1 (CD31) knockout (KO) mice exhibit excessive megakaryocytopoiesis accompanied by increased numbers of megakaryocytes associated with the stromal niche rather than the vascular niche. During earlier stages of megakaryocytopoiesis in KO marrow, an expanded Lin(-)Sca-1(+) c-kit(+) hematopoietic stem cell (HSC) population and increased quiescent Lin(-) progenitor pool were identified. During the later stages of megakaryocytopoiesis, CD31KO megakaryocytes exhibited abnormal adhesion/transmigration behaviors. Lastly, KO animals exhibited excessive splenic extramedullary megakaryocytopoiesis, which likely compensates for the impaired marrow megakaryocytopoiesis, resulting in normal peripheral platelet number. Thus, PECAM-1 modulates megakaryocytopoiesis in a hierarchic manner, functioning as a thermostat to "fine-tune" megakaryocytopoiesis.
血小板内皮细胞黏附分子-1（PECAM-1，即CD31）基因敲除（KO）小鼠表现出巨核细胞生成过多，伴有与基质龛而非血管龛相关的巨核细胞数量增加。在基因敲除小鼠骨髓中巨核细胞生成的早期阶段，可识别出一个扩大的Lin(-)Sca-1(+)c-kit(+)造血干细胞（HSC）群体以及静息的Lin(-)祖细胞池增加。在巨核细胞生成的后期阶段，CD31基因敲除的巨核细胞表现出异常的黏附/迁移行为。最后，基因敲除动物表现出脾脏髓外巨核细胞生成过多，这可能补偿了受损的骨髓巨核细胞生成，从而导致外周血小板数量正常。因此，PECAM-1以分级方式调节巨核细胞生成，起到“微调”巨核细胞生成的恒温器作用。
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